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While low levels of ROS are necessary for normal sperm functions such as maturation and fertilization, excessive ROS accumulationdriven by conditions like varicoceles, infections, or exposure to tobacco, alcohol, radiation, and environmental toxinscan lead to significant sperm damage

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These findings elucidate a S-palmitoylation-dependent regulatory mechanism of cellular ATG2, which may represent a broad regulatory strategy for lipid transport mediated by bridge-like transporters within cells