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These lipid-protein complexes, termed lipoproteins, vary in their content of lipid and protein

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Transcriptomic analyses have identified upregulation of acyl-CoA oxidase 1 (ACOX1), a key enzyme in the peroxisomal -oxidation pathway regulated by PPAR, as a major node in hepatic lipid metabolism in humans, mice, and rats

Osborne JC, Schaefer EJ, Powell GM, Lee NS, Zech LA

The explanation for this process is that cholesterol and PI(4)P are synthesised at two different locations, i.e., the endoplasmic reticulum for sterols and the trans-Golgi network and plasma membrane for PI(4)P, so the two lipids do not compete but rather can be exchanged