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It should be noted that the prototype SGLT1 and SGLT2 blocker, phorizin, did not achieve suitability for human use due to considerable problems (i.e., diarrhea, dehydration, and malabsorption due to small intestine SGLT1 inhibition) [42,43,44]
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There is also lots of research to show that pain can increase with repeated painful stimulation, and therefore discomfort may rise with each injection
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