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56 If FNAB is required for diagnostic confirmation, cytopathology demonstrates pleomorphic pigmented cells in a solid or vacuolar pattern with large melanosomes, compared to spindle cells with smaller melanosomes seen more commonly in uveal melanoma

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22,23 They are now particularly used as surrogate end points in clinical trials, 24,25 pharmacological treatment 26,27 of major pathological conditions including cancer 2832 and heart disease

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This particular lesion carries a 5-10% risk of degenerating into malignant melanoma over a 50 year lifetime