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The direct evidence showing the involvement of PCS in GS-conjugate metabolism is the defects in the turnover of GS-bimane shown in the Arabidopsis AtPCS1-deficient mutants [21, 47]

PMID: 40160974

Endostatin in disease modulation: from cancer to beyond

Diabetologia 60:15661576 Wang GS, Hoyte C (2019) Review of Biguanide (metformin) toxicity

However, the critical requirement of neutrophils for antimicrobial host defense limits the utility of therapies that broadly reduce neutrophil numbers or functional responses
