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doi: 10.3390/nu9010001, Summary Keywords vitamin B 12 , health care, hospitalization, public health burden, clinical diseases Citation de Carvalho LP, Akamine N, Di Pietro MS, Frana CN, Oliveira R and Lopes RD (2026) Vitamin B 12 deficiency and its impact on healthcare: a population-level analysis and call for action

Across six randomised, double-blind, placebo-controlled trials involving over 900 participants, the adverse event profile was essentially identical to placebo

Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding author

Assessing During Break Periods Break periods serve an important assessment function

Support should involve reducing any gastritis and H pylori levels and bypassing the enteric route for B12 absorption by using sublingual B12 or injections