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This is why acanthosis nigricans is commonly associated with: Overweight or obesity Type 2 diabetes Prediabetes Polycystic ovary syndrome (PCOS) Other hormonal or endocrine conditions In children and teenagers, its presence is often an early warning sign of insulin resistance long before diabetes develops

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Jones and Gilligan 1983)

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796 Proteomic analysis based on tandem mass tag showed that GSH metabolic pathway was downregulated during myocardial ischemia, especially GPX4 in the early and middle stages of myocardial infarction