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In the context of STAT pathwaymediated M2 polarization driving an aggressive tumor phenotype, Garcinone E blocks the M2 polarization process by inhibiting STAT6 phosphorylation, while Mongolian Iris Extract specifically targets the IL10/STAT3/PDL1 axis to reverse M2mediated immune evasion [228, 229]

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241 Mutations in the SIRT2 gene have also been reported in human cancers, impairing genome maintenance and promoting tumorigenesis

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Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis

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Tesamorelin is used to investigate modulation of neurotransmitter-related signaling pathways, including gamma-aminobutyric acid (GABA)associated networks and glial metabolic markers

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