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While GHK-Cu (with certain limitations) and L-Theanine have now been included on to the Category 1 bulks list, various peptides were added to the Category 2 bulk drug substance list (those that raise significant safety concerns)

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Blood J Am Soc Hematol 111(7):34793488 Liu J-M et al (2003) The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo

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doi: 10.1056/NEJMoa1606038 130 ZhuCSongZWangASrinivasanSYangGGrecoRet al

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Together, these enzymes help maintain genomic integrity and support normal cellular function over the lifespan

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2000), several studies have demonstrated good concordance of the assay with the in vivo transgenic rodent (TGR) somatic mutation assay and also high sensitivity of 92.1% (35 out of 38 chemicals correctly identified) for detecting human IARC group 1 and Group 2A carcinogens, comparable to the TGR assay with 90.3% (Kirkland et al

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