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In addition, IGF-1R can also regulate cell adhesion by influencing matrix metalloproteinase (MMP) expression, which is essential in the degradation of ECM components, including gelatin and collagens, and plays a crucial role in helping single cancer cells to break away from primary tumors and blood vessels during cancer metastasis (Figure 1) [65,66]

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Blood levels peak around age 20 at approximately 200 ng/mL and decline to roughly 80 ng/mL by age 60, correlating with diminished skin elasticity and regenerative capacity