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Surprisingly, multiple ALS-causative mutations in FUS/TLS increase FUS/TLS interaction with SMN, thereby affecting the normal function of SMN by both reducing Gem bodies and changing steady-state levels of some snRNAs in transgenic mouse tissues and patient fibroblasts expressing mutant FUS/TLS

Research & Evidence Disclaimer: Information presented in this article includes references to preclinical (animal and laboratory) research

Serine deficiency exacerbates oxidative stress, reducing antioxidant enzyme activity and glutathione levels in aging mice and intestinal porcine epithelial cells (IPEC-J2 cells) 68,69

Bioactive compounds Dietary bioactive compounds or phytochemicals are substances produced by the secondary metabolism of plants in response to environmental stressors (Reference Kumar, P and Kumar149)

Drugs 63, 25012520