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High MYC expression activates the E3 ligase KLHL42, which is responsible for pRB1 ubiquitination and degradation and subsequently confers resistance to CDK4/6i to cancer cells
Another device to enhance N-to-B drug delivery is Impel Neuropharmas Precision Olfactory Delivery (POD ), which delivers either powder or liquids as aerosols
doi: 10.1016/j.appet.2017.01.017
doi: 10.1684/mrh.2011.0285 298
The closest cousin is the semaglutide and Cagrilintide combination, the CagriSema concept
