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This discovery prompted the development of receptor-selective somatostatin analogues, including lanreotide, vapreotide, and pasireotide

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In further embodiments, the auris formulation or composition contains a viscosity enhancing agent or viscosity modulating agent sufficient to provide a viscosity of between about 10 and 1,000,000 centipoise, between about 100 and 1,000,000 centipoise, between about 500 and 1,000,000 centipoise, between about 750 and 1,000,000 centipoise

Methylation is the addition and removal of a methyl group (-CH 3 ) to amino acids, DNA, and other enzymes or proteins

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