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Thus, CaSR could at least partially account for the beneficial action of -Glu-Cys, although this hypothetical mechanism must be verified in experiments that employ model animals such as mice with a genetic ablation of CaSR

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Generation of iPSC-derived kidney organoids recapitulating human Fabry nephropathy To generate Fabry kidney organoids, GLA-mutant human iPSCs were differentiated into kidney organoids using an adherent cell culture protocol 15,16
