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Description
Bioinformatics 2022, 38 (2), 568569
10.1038/s12276-020-00504-8 12
The upregulated urea cycle removes -amyloid and ammonia on one hand, while on the other, overproduction of the urea cycle metabolite ornithine leads to the overexpression of the enzyme ornithine decarboxylase 1 (ODC1), which produces excessive putrescine that subsequently degrades into GABA, H 2 O 2 and ammonium (see previous section)
Boosts energy level
These differences between N5-Tr vs N5-WT islets recapitulate those we reported in BL/6J vs BL/6N islets (see Figure 1B in [33]), suggesting that, as in that model, the lack of NNT prevents mitochondrial NADPH oxidation at low glucose and in the presence of FCCP without affecting NADH production (see Figure 1 C,D,F in [33])
