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MiR-24-3p In degenerative nucleus pulposus cells from patients with intervertebral disc degeneration, miR-24-3p was shown to target the 3-UTR of IGFBP-5 mRNA, downregulating IGFBP-5 and enhancing ERK activation [101]

COL-I comprises almost 90% of organic material during the formation of inorganic bone matrix to support the structure of osteogenesis 33,35,36

Therefore, the adverse effects of PCOS could threaten the quality of life in women 10

A potential explanation is that the maintenance of NAD + pools may help to restore the activities of different NAD + -dependent proteins to drive distinct metabolic processes, respectively enhancing GAPDH-mediated glycolytic reaction and elevating SIRT3-induced OXPHOS in macrophages activated with LPS at different time points

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