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Overexpression of IGF-I receptor in OVCAR-3 cells had no protective effect, however ectopic expression of a constitutively active AKT2 did offer protection from the cytotoxic effects of ascorbyl stearate

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Pulido-Valdeolivas I

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The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway can be activated by PIK3CA mutation, loss of phosphatase and tensin homolog (PTEN), or other mechanisms (e.g., PIK3CB mutation, PIK3CB mutation, AKT1 mutation, TSC1/TSC2 inactivating mutation, MTOR mutation) to promote PCa cell survival and proliferation independent of AR signaling (33)

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[6] Toxicological seizures (e.g., seizures due to cocaine, local anesthetics, lindane, or theophylline)

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Turns out they werent working anyway

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