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The hepatotoxicity of PZA is dose-dependent, especially at doses above 40 mg/kg, and correlates with its hepatic metabolism, suggesting a direct toxic effect rather than a hypersensitive or immune-mediated mechanism

10.1038/s41467-017-01311-y 4 AkaikeT.MoritaM.OgataS.YoshitakeJ.JungM.SekineH.et al (2024)

[DOI] [PubMed] [Google Scholar] 260.Zettinig G, Hanselmayer G, Fueger BJ, Hofmann A, Pirich C, et al

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The objective of the present work was to investigate the effect of host- and pathogen-derived glutathione on Bd growth and infection