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NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores

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Our research shows a 35% decrease in oxidative stress markers

Interestingly, we have shown that activation of S1P receptors in astrocytes improve their ability to induce maturation, neurite outgrowth and arborization of neuronal precursor cells through increase of extracellular matrix components