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Description
The only real guidance we have is from the pivotal Cell paper published in 2017 where FOXO4-DRI was introduced to the world, in which the peptide was well-tolerated without any side effects

PCAC recommendations are non-binding

Drink water away from meals or at least don't flood meals with large quantities
If preclinical toxicology suggests that a drug candidate has effects on cardiac conduction or effects on human etheragogo channels, continuous ECG monitoring and triplicate ECGs obtained in conjunction with plasma sampling for PK evaluation would be useful once the dose or range of doses to take forward into further development is determined
Retatrutide data comes from 48-week studies
