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no clinical efficacy or therapeutic utility is implied or should be inferred

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Human studies have shown that PYY delays gastric emptying and promotes satiety (165), while short-term intravenous administration of PYY3-36 , at doses generating physiologic postprandial blood excursions, was shown to decrease calorie intake by approximately 30% in lean and obese subjects, without causing nausea, affecting food palatability, or altering fluid intake, nor was it followed by compensatory hyperphagia (166)

The off-period also allows receptor sensitivity to reset, ensuring the next cycle works as effectively as the first

The MOTS-c peptide , encoded in mitochondrial DNA, has therefore been investigated as a potential tool for extending healthspan and delaying age-related decline