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The arc from an encouraging 12-week readout to a null 24-week pivotal result is a textbook example of that shrinkage, and it is a pattern seen across the metabolic-drug field, not a quirk of this peptide

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While clinical studies have demonstrated its fat-reducing potential, AOD-9604 has not been fully validated as an FDA-approved weight loss therapy

Due to its shorter sequence, TB-500 offers enhanced metabolic stability and amenability to synthetic optimization compared to the parent protein

A., Zhang, H., Mladenovic, L., Tseng, Y