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Some commenters requested that we not make any updates to the expanded Model at this time stating it was too soon, and that we should wait to make proposals after HHAs have seen data on the proposed measures

Functions as a for metabolic reaction required for synthesis of purines and pyrimidines: co-enzyme The reaction depends on methyl cobalamin as a co-factor and is also dependent on folate, in which the methyl group of methyltetrahydrofolate is transferred to homocysteine to form methionine and tetrahydrofolate

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