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Elevated oxidative stress tends to promote a pro-inflammatory M1 phenotype, while a more reduced environment facilitates M2 polarization, fostering tissue repair and immune regulation (62)

Am J Physiol (1999) 277(6):L106788

Although the literature is not entirely consistent in affirming vitamin D deficiency in RLS or the amelioration of RLS symptoms with vitamin D therapy, the collective studies ocerall indicate that vitamin D deficiency is common enough in RLS patients to recommend that RLS patients should have their vitamin D levels checked and any deficiency corrected as a standard of care

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doi: 10.1016/j.neuint.2020.104688