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Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

Injecting on training days, either before or after exercise, potentially provides GHK-Cu when repair mechanisms are most active

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Our own research has shown that GHK promotes the migration of lung fibroblasts from aged mice (24 months old) in a dose-dependent manner (Figure 1), indicating that it can revert aged fibroblasts to a more youthful phenotype, potentially through the activation of mesenchymal progenitor cells