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Though low serotonin levels may give rise to an attack, some evidence suggests that elevated serotonin levels may contribute to migraine pathology during an attack (Sakai 2008

doi:10.1126/sciadv.aax6328

[DOI] [PMC free article] [PubMed] [Google Scholar] 239.Takeuchi T, Kubota T, Nakanishi Y, Tsugawa H, Suda W, Kwon ATJ, Yazaki J, Ikeda K, Nemoto S, Mochizuki Y, et al

Soft Agar Colony Formation Assay Cells were plated in 6 well plates at a density of 2.510 4 cells per well

Nonetheless, this was a single-blind study conducted over a brief period of 8 weeks (Table 3)
