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It also faces certain development challenges, showing an overall trend of coexisting potential and opportunities, which can be summarized in the following aspects

MAPK pathways Mammalian cells express three major classes of MAPKs, the extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinase/stress-activated protein kinases (JNK/SAPK) and p38 kinases, the activation of which results in the stimulation of transcription factors and the regulation of the expression of cell cycle proteins [ 32 , 33 ]

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Cellular signaling can take many distinct forms, each of which requires a unique set of ligands and receptors