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Active targeting is achieved by adding a ligand specific to overexpressed substances on the cell surface or intracellular surface of the targeted cell to the surface of the vector

Marom M, Hagalili Y, Sebag A, Tzvier L, Atlas D (2010) Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx

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Thus, where genotype is known, there is a strong case for initiating serum vitamin B 12 monitoring from initiation of metformin treatment in people with the AA genotype but deferring this until 10 years of treatment in the rest of the population who have no other risk factors

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