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Among these, Asp f 6 (Mn-Sod), Asp f 8 (P2 acidic ribosomal protein), Asp f 11 and Asp f 27 (cyclophilins), and Asp f 28 and Asp f 29 (thioredoxins) have been shown to belong to families of cross-reactive pan-allergens.64 This fact could imply autoimmunity problems in human patients