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In this system, the DNA damage detected in the absence of the Fanconi Anaemia DNA repair pathway is comparable to the damage detected by incubating cells with 0.5 mmol L 1 FA, which is close to the level reported for cellular GSH

J.MccookJ

A biophysically based mathematical model for the catalytic mechanism of glutathione reductase

Although this study provides a proof-of-principle that FRET studies can theoretically be done in vivo , Spatio-temporal resolution is lower than in slices, which might in part explain why such in vivo experiments have not been reproduced

However, our decision to focus solely on PA levels was primarily was influenced by several factors (i) existing literature has indeed focused on the vanin-1/cysteamine axis, particularly its role in oxidative stress., while the vanin-1/PA pathway is often-overlooked