igf-1 des vs lr3 reddit LR3: muscle growth, or just hype?, A peptide often mentioned in muscle growth circles — but what does the science actually say about IGF-1 LR3?, IGF-1 stands for Insulin Growth Factor 1, a IGF-1 LR3 Before and After:
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At least in theory

In line with this observation, binding free energy predictions indicated that the first designed L-peptide (E1) which differs from native FOXO4 sequence by 4 mutations, binds to CR3 more strongly than DRI (Table 1)

It likely directly damages the hippocampus through glutamate excitotoxicity

doi: 10.3390/molecules19021843

In 2022, Wang et al