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Around 3-8% report appetite changes, both increases and decreases have been documented

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Narine M, Azmi MA, Umali M et al (2023) The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

To translate this to human parameters, we apply the FDAs Body Surface Area (BSA) normalization method
Some substances get punted to February 2027 or later if the committee feels the data are insufficient
