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Whether administration of allopurinol in these conditions would provide human benefit is still unknown

Study appraisal and synthesis methods We assessed the quality of studies using the RoB2 tool recommended by the Cochrane Handbook, the NewcastleOttawa Quality Assessment Scale (NOS), the checklist recommended by Agency for Healthcare Research and Quality (AHRQ), and the quality evaluation tool recommended by the National Institutes of Health (NIH)

The authors of those individual studies as well as the reviewers have generally attributed the lack of performance benefits with L-carnitine to the inability to increase resting muscle carnitine concentrations

doi: 10.1021/bi0358824

10.1111/j.1476-5381.2010.00745.x Br