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The in vitro 4T1 model is deprived of major components of the TME, including M2 macrophages and cancer-associated fibroblasts (CAFs), which release factors that increase MMP secretion and alter the invasive characteristics of cancer cells (Chen et al
Several PLP-dependent C-S lyases (e.g., cysteine S -conjugate -lyases) in primary metabolisms, xenobiotics detoxifications 33 and secondary metabolite biosynthesis have been reported 34,35
SM is well-known for its diverse therapeutic properties, including promoting blood circulation, removing blood stasis (Wei et al., 2023), calming the mind, tonifying the blood, and enhancing the Qi. Over the centuries, the utilization of SM has exhibited remarkable efficacy in addressing a wide spectrum of ailments, including cardiovascular, neurological, cancer, osteoporosis, liver, gynecological, and chronic kidney diseases
McCormack RM, de Armas LR, Shiratsuchi M, Fiorentino DG, Olsson ML, Lichtenheld MG, et al
Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low
