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FTH neuron-specific knockout (FTH-KO) mice are more susceptible to ferroptosis after TBI, and the absence of FTH offsets the protective effect of melatonin on ferroptosis induced by TBI, 659 suggesting that melatonin plays a protective role at least in part by inhibiting FTH-mediated ferroptosis in neurons after TBI

However, the study had limitations regarding sample size, geographical location, and exclusion of patients with diagnosed mood disorders, which could have influenced sleep patterns

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