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Acknowledgements We thank all the laboratory members for helping with reading and commenting on the manuscript

Following medium change, cells were treated as indicated

This relationship can be explained by the release of H 2 O 2 due to polyphenol oxidation [52]

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The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program
