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Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease

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Common presentations include: Heavy menstrual bleeding (menorrhagia) and prolonged periods Iron deficiency anemia secondary to blood loss Pelvic pressure, pain, or a sensation of fullness Bladder frequency or incomplete bladder emptying (from anterior fibroids compressing the bladder) Constipation or rectal pressure (from posterior fibroids) Abdominal distension Menstrual clotting Recurrent pregnancy loss or difficulty conceiving Submucosal fibroids, those growing into the uterine cavity, are most strongly associated with heavy bleeding and reduced fertility. Types of Uterine Fibroids Fibroids are classified by location: Intramural: Embedded within the myometrium (uterine muscle wall)

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The RNAs of RNA-directed DNA methylation

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