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1 Introduction The pathology of ophthalmic diseases involves various mechanisms of cell death, including apoptosis, necrosis, and autophagy ( The key membrane protein xCT related to ferroptosis was discovered as early as the 1980s ( This phenomenon is observed not only in mammals but also in plants, protozoa, and fungi, including Magnaporthe oryzae and Caenorhabditis elegans ( Figure 1 ) ( Figure 1 It is widely believed that ferroptosis primarily results from an overload of intracellular reactive oxygen species (ROS) dependent on iron, combined with a reduction in the detoxifying activity of GPX4, leading to an imbalance in ROS production and clearance ( This review delves into the latest developments and future prospects in the research of ferroptosis in corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Ono H., Nishijima Y., Adachi N., Sakamoto M., Kudo Y., Kaneko K., Nakao A., Imaoka T