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[20] Symptoms like irritability, anxiety, poor sleep, gross motor problems or problems with coordination, tics, seizures, vision problems, developmental delay and/or slowing of typical development, and depression have been reported in those with FRAs and while testing folate levels in the CSF is too invasive, a test for folate receptor antibodies is available

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476,477 Genetic code reprogramming by substituting endogenous aaRSs for more promiscuous mutants, such as PheRS A294G, LeuRS D345A, and editing deficient ValRS T222P, has also been reported