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The process of mitochondrial fission requires that the cytosolic protein, dynamin-related protein 1 (Drp1), be recruited to the outer mitochondrial membrane

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Coronal T2-weighted (T2W) MRI scans (2D TurboRAGE) of the whole brain were performed with a vertical-bore 9.4 T Bruker AVANCE 400WB imaging spectrometer with a 250 mTm 1 actively shielded imaging gradient insert (Bruker BioSpin, Billerica, MA) controlled by Paravision software

The dose-response curve in clinical trials was remarkably linear

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