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The generator delivers electrical pulses to stimulate the vagus nerve at preset intervals or on demand ( 4 Mechanisms of the effects of VNS on neurodegenerative diseases VNS is a therapeutic intervention that involves the delivery of electrical pulses to the vagus nerve via implanted devices, modulating brain activity to treat neurological conditions ( 4.1 Regulation of neurotransmitters When dysregulated, neurotransmitters, which serve as endogenous chemical messengers for signal transmission across synapses (between neurons) and neuromuscular junctions, play central roles in the pathogenesis and progression of NDDs ( VNS may ameliorate neurodegenerative disorders by modulating neurotransmitter release and enhancing neuronal activity and synaptic plasticity within neural circuits ( 4.2 Reducing protein misfolding and aggregation Abnormal protein aggregation and misfolding constitute key pathological bases for neuronal decompensation and apoptosis

mGluRs are divided into three groups based on their sequence homology, signal transduction pathways, and pharmacological profiles: Group I (mGluR1 and mGluR5), Group II (mGluR2 and mGluR3), and Group III (mGluR4, mGluR6, mGluR7, and mGluR8)