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This induced a significant increase in the activity of cytotoxic T cell-mediated anti-tumor response and the infiltration of CD8 + T cells into the tumor microenvironment [249, 250]

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Advances in Glutathione Research for Disease Research Targeted therapy for GSH metabolism has become a research hotspot, and metabolomics and proteomics technologies have also provided powerful tools for GSH-related research: Targeting GSH metabolism : Inhibiting key molecules such as GCLC, xCT (cysteine uptake carrier) or SLC25A39 (mitochondrial GSH transporter), or using GSH-depleting nanozymes, has shown the potential to enhance ROS-mediated tumor cell death and improve related disease symptoms in preclinical models (such as cell models and animal models), providing new strategies for disease treatment

In addition, protein crash with 200 L 10% metaphosphoric acid (MPA) added to the filtered sample supernatant at 4 C was performed to minimise HPLC fouling

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