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Management of the cat with diabetes mellitus: sodiumglucose cotransporter-2 inhibitor (SGLT2i) therapy Mechanism of action of SGLT2is In the kidney, glucose is freely filtered at the glomerulus, and sodiumglucose cotransporter (SGLT) membrane proteins expressed in proximal renal tubules (SGLT2 and, to a lesser extent, SGLT1) actively reabsorb all filtered urinary glucose

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