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doi: 10.1111/j.1365-2222.2007.02821.x

Once absorbed, it undergoes hepatic detoxification, where approximately 75% is metabolized primarily by glucuronidation, sulfonation, and oxidation via CYP2E1

Pasalic D, Betancourt-Cuellar SL, Taku N, Ludmir EB, Lu Y, Allen PK, Tang C, Antonoff MB, Fuller CD, Rosenthal DI, Morrison WH, Phan J, Garden AS, Welsh JW, Chang JY, Liao Z, Erasmus JJ, Nguyen QN

[183] showed that HRS reduces apoptosis induced by skin I/R and improves flap survival modulation of the Bax/Bcl2 ratio and inhibition of the activated Apoptosis SignalRegulating Kinase 1/JNK pathway