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Des perturbations de cet quilibre sont observables dans des situations pathologiques varies, telles que les tats de dnutrition, les troubles cardiovasculaires, les insuffisances respiratoires, le diabte, l'hmodialyse.The choice of this model was guided by the fact that the muscular functions (excitability, contractility) constitute a good reflection of the nutritional, metabolic and electrolyte balance of the organism

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doi: 10.1371/journal.ppat.1008599 112 SkokM

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To further enhance the BBB properties of the models, the medium was supplemented with cARLA (250 M 8-(4-chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, 17.5 M Ro-20-1724, 3 mM LiCl, 3 M A83-01