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Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications

Within the tumor microenvironment, mitochondria profoundly impact immune responses by modulating T-cell survival and function, macrophage polarization, NK cell cytotoxicity, and neutrophil activation

Active Akt phosphorylates multiple targets including Bad (preventing it from inhibiting anti-apoptotic Bcl-2), MDM2 (stabilizing p53), FOXO transcription factors (preventing pro-apoptotic gene expression), mTOR (promoting protein synthesis)

And they also found that an elevated selenium intake prior to breast cancer diagnosis has contributed to improve specific survival rate, as evidenced by a hazard ratio of 0.69 (95% confidence interval: 0.52-0.92), and clinical outcomes (59)