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Second, there is a chance that bacteria may develop resistance against the combination

Mar 2010;48(3):269-274

10.1016/j.nlm.2015.07.013 183 PattersonP
Pathogenic landscape of idiopathic male infertility: New insight towards its regulatory networks

Analogously, the MS gradient revealed by the metabolic principal path shows a spatially ordered, monotonically increasing progression of MS mode values along the caudo-rostral axis, mapping distinct functional brain specializations into a continuous biochemical space