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This lends support to the notion that the main physiological roles of these enzymes is in regulating the concentrations of lipid peroxides that are poorly or not metabolized by catalase or APX, or in peroxide sensing

413 Partial ablation of astrocytes in the prefrontal cortex of healthy rats (by injection of gliotoxin L--aminoadipic acid) resulted in the development of depressive-like behaviours, whereas injection of neurotoxin ibotenate did not have such an effect

N-acetylcysteine transforms oxidized glutathione into its active form

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