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However, the exact mechanisms by which insulin performs these distinct roles is not fully understood

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10.1126/scitranslmed.abg6428

The use of integrative proteomic-genomic techniques to analyze the samples of patients may be a reliable strategy

When -oxidation is limited, tumors avoid ferroptosis by (i) reducing PUFA incorporation into membranes 346 , (ii) deploying extramitochondrial ubiquinol recycling to trap lipid radicals 347,348 , and (iii) using the mitochondrial dihydroorotate dehydrogenase-ubiquinone axis to detoxify lipid peroxides in the inner membrane 349