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doi: 10.1002/stem.2000
Enhanced NRF2 activation and its protective effects against ROS have also been observed in multiple human cancer types, often due to mutations in the KEAP1 gene (Romero et al
It can also lead to cataracts or numbness or weakness in the arms or legs, and it often starts in the late teen or early adult years
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However, consensus has not been reached regarding the regulation of ROS generation by PER1/2
